Neurobiology of Disease Adolescent Cocaine Exposure Causes Enduring Macroscale Changes in Mouse Brain Structure

Anne L. Wheeler,1,2 Jason P. Lerch,1,3,4 M. Mallar Chakravarty,5,6,7 Miriam Friedel,1,3 John G. Sled,1,3,4 Paul J. Fletcher,8,9 Sheena A. Josselyn,1,2,9,10 and Paul W. Frankland1,2,9,10 1Program in Neurosciences and Mental Health, The Hospital for Sick Children, Toronto, Canada, M5G 1X8, 2Institute of Medical Science, University of Toronto, Toronto, Canada, M5S 1A8, 3Mouse Imaging Centre, The Hospital for Sick Children, Toronto Centre for Phenogenomics, Toronto, Canada, M5T 3H7, 4Department of Medical Biophysics, University of Toronto, Toronto, Canada, M5G 2M9, 5Kimel Family Translational Imaging Genetics Laboratory, Research Imaging Centre, Centre for Addiction and Mental Health, Toronto, Canada, M5T 1R8, 6Department of Psychiatry, University of Toronto, Toronto, Canada, M5T 1R8, 7Rotman Research Institute, Baycrest, Toronto, Canada, M6A 2E1, 8Biopsychology Section, Neuroscience Research Department, Centre for Addiction and Mental Health, Toronto, Canada, M5T 1R8, 9Department of Psychology, University of Toronto, Toronto, Canada, M5S 3G3, and 10Department of Physiology, University of Toronto, Toronto, Canada M5S 1A8